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Effects
The effects of lactic acid bacteria
Effect 4: NK activity effect of nano-type Lactobacillus®nEF
The strength of NK cells in attacking cancer cells and virus-infected cells is called NK activity, and is considered one of the indicators of immune strength. It is known that NK activity is greatly affected by various factors.
NK cell activity enhancement experiment
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Exam Content
Nano-sized lactic acid bacteria nEF was orally administered to healthy mice to examine its effect of enhancing the activity of splenic natural killer (NK) cells.
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Test results
NK activity was enhanced in a dose-dependent manner by administration of nEF (Figure 1).
High doses of nEF (5 mg/kg BW) significantly enhanced NK activity (P<0.05).
The NK cell-related factors in white blood cells were also high (Figure 2).
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Fig. 1 Splenic leukocyte NK activity (E:T ratio = 2:1)
Figure 2 NK cell-related factors in leukocytes
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Commentary
The dose-dependent increase in NK activity suggested that nEF activates splenic NK cells through intestinal immunity. In the high-dose group of nEF (5mg/Kg/BW/day), a statistically significant difference was observed in the mRNA expression levels of IFN-γ and Perforin 1, factors related to NK cell activity.
